Join Us at the Workshop
Beyond Rule of 5 - Live Lab
The bRo5 Live Lab is a science-first workshop dedicated to advancing oral delivery strategies for molecules that push beyond Lipinski’s Rule of 5. Running alongside the Advancing Drug Development Forum (ADDF), it builds on the Forum’s reputation for high-quality peer exchange while offering a distinct space for formulation scientists, CMC leaders, biotech innovators, and CDMO partners.
A Working Format for Solving Real Challenges
The first event in our Live Lab series, bRo5 is an interactive working session built around real-world challenges in oral drug delivery. Participants engage directly with one another—sharing experiences, testing ideas, and exploring enabling technologies. Together, they address permeability, solubility, and bioavailability barriers in some of the most complex modalities, including peptides, degraders, macrocycles, and RNA-targeting small molecules.
Agenda
Kickoff Keynote
Start off the day with a bold scientific vision from Dr. Jennifer Petter, scientific founder of Arrakis Therapeutics, as she shares her groundbreaking work targeting RNA and designing truly novel oral therapies.
Setting the Stage: The Rule of 5 Debate
In a provocative conversation, we examine the history, utility, and limitations of the Rule of 5. Is it still a helpful compass—or a barrier to innovation?
Roundtable of Enabling bRo5 Advanced Technologies for Development
Hear from experts on the enabling formulation and delivery technologies that help move non-traditional molecules forward. Expect real-world data on the round tablets, lipid systems, nanoparticle, RNA-Targeted Small Molecules, and emerging AI technologies that are changing the game.
Moderator: Hector Guzman, Vice President, CMC Technical Operations, Newleos Therapeutics
Hands-On Session
Bring your questions—and your toughest formulation challenges—to our interactive roundtable session. Each table will feature a dedicated expert, guiding deep-dive discussions on oral bioavailability, permeability, regulatory strategy, and more. This is your chance to workshop your toughest roadblocks with the best minds in the field.
We’ll close the session by sharing key insights from each table and building a roadmap for what’s next in oral delivery innovation.
Moderator: Padma Narayan, Vice President, CMC, New Co.
Fireside Chat: Transformation of the Boston Biotech
The Fireside Chat ignites the stage with Boston’s biotech trailblazers in a raw, no-filter conversation about what’s driving transformation right now. Expect bold perspectives, unvarnished lessons, and breakthrough ideas that challenge the status quo and spark new possibilities. This is where the energy peaks, the insights get real, and the future of drug development takes shape in front of you.
Brad Loncar, Founder, BiotechTV
Joshua Cohen, Founder & CEO, Amylyx Pharmaceuticals
Ivana Magovcevic - Liebisch, PhD, JD, Chief Executive Officer and President, Vigil Neuroscience
Sponsors
